About Ceftazidime Third Generation Cephalosporin antibiotic, Parenteral antibiotic. Mechanism of Action of Ceftazidime Ceftazidime is a 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Ceftazidime inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Ceftazidime.It is more active against pseudomonas. Indications for Ceftazidime 1.Febrile neutropenic patients with haematological malignancies 2.Burn infections 3.Respiratory tract infections 4.Urinogenital tract infections 5.Bone & Joint infections 6.Septicemia 7.CNS infections 8.Skin & wound infections 9.Meningitis.