About Itraconazole A synthetic triazole derivative, Systemic Antifungal. Mechanism of Action of Itraconazole Itraconazole is a fungicidal or fungistatic depending on the drug concentrations. It inhibits the conversion of Lanosterol to 14 demethyl Lanosterol by inhibiting the cytochromeP450 enzyme 14 alpha demethylase and impair ergosterol synthesis in fungi. Indications for Itraconazole 1.Histoplasmosis 2.Blastomycosis 3.Aspergillosis 4.Oropharyngeal candidiasis 5.Oesopharyngeal candidiasis 6.Vaginal candidiasis 7.Sporotrichosis 8.Coccidioidomycosis 9.Paracoccidioidomycosis 10.Tinea pedis 11.Tinea corporis 12.Tinea versicolor 13.Tinea cruris 14.Chromomycosis