About Torsemide Pyridine-sulfonylurea class Loop Diuretic, Antihypertensive,in CHF, Diuretic. Mechanism of Action of Torsemide Torsemide is a high ceiling loop diuretic which exerts it`s diuretic action by acting at site-2(thick ascending loop of Henle). It binds to Na+K+2Cl- symporter and inhibits Na+K+2Cl- co transport in luminal membrane of thick ascending loop of Henle. It inhibits sodium and chloride re absorption and promotes excretion of sodium, water, chloride, potassium, calcium, and magnesium. Torsemide does not significantly alter glomerular filtration rate, renal plasma flow, or acid base balance. Torsemide increase local prostaglandin synthesis and increases systemic venous capacitance and decreases left ventricular filling pressure. This causes relief in left ventricular failure and pulmonary edema. It causes renal and peripheral vasodilatation and decrease in peripheral resistance.