is a relatively selective alpha-2 adrenergic receptor agonist (topical intraocular pressure lowering agent). INDICATIONS indicated for the reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension. DRUG INTERACTIONS Antihypertensives/Cardiac Glycosides Because ALPHAGAN� P (brimonidine tartrate) may reduce blood pressure, caution in using drugs such as antihypertensives and/or cardiac glycosides with ALPHAGAN� P (brimonidine tartrate) is advised. CNS Depressants Although specific drug interaction studies have not been conducted with ALPHAGAN� P (brimonidine tartrate) , the possibility of an additive or potentiating effect with CNS depressants (alcohol, barbiturates, opiates, sedatives, or anesthetics) should be considered.