Medicine Description trexan 2.5mg
Trexan 2.5 mg 100 tablets is a medication that contains methotrexate, which acts by inhibiting the enzyme dihydrofolate reductase. This inhibition disrupts the synthesis of nucleic acids and subsequently interferes with the proliferation of rapidly dividing cells, such as cancer cells and cells involved in autoimmune responses. By blocking the conversion of dihydrofolate to tetrahydrofolate, methotrexate reduces the availability of folate, essential for DNA synthesis and repair. This mechanism underpins its use in conditions like certain leukemias, lymphomas, and autoimmune disorders, where excessive or uncontrolled cell growth occurs.
Indications and Uses of Trexan 2.5 mg 100 tablets
- Management of various types of cancers, including acute lymphoblastic leukemia and non-Hodgkin lymphoma.
- Treatment of autoimmune diseases such as rheumatoid arthritis and psoriasis.
- Induction of remission in certain conditions requiring immunosuppressive therapy.
Side Effects of Trexan 2.5 mg 100 tablets
- Nausea and vomiting
- Mouth sores or ulcers
- Fatigue and weakness
- Hair loss
- Increased susceptibility to infections
- Liver function abnormalities
- Pulmonary toxicity
Storage and Handling
Store Trexan at room temperature, away from excess moisture and heat. Keep out of reach of children and pets. Protect from light and ensure the medication is in a securely closed container.
Patient Advice and Precautions
Patients should remain under close medical supervision during treatment, with regular blood tests to monitor liver function and blood cell counts. It’s essential to hydrate adequately and avoid alcohol consumption. Inform healthcare providers of any existing medical conditions or medications, as interactions may occur.