Medicine Description methotrexate 2.5mg
Methotrexate 2.5mg Tablets is a medication that functions as an antimetabolite. It primarily acts by inhibiting the enzyme dihydrofolate reductase, which is crucial for the conversion of dihydrofolate to tetrahydrofolate, a vital cofactor in the synthesis of nucleotides. By blocking this enzyme, methotrexate effectively reduces the availability of folate, thereby disrupting the synthesis of DNA and RNA, leading to inhibition of cell division, particularly in rapidly proliferating cells such as cancer cells and inflammatory cells. This mechanism contributes to its effectiveness in treating malignancies and certain autoimmune disorders.
Indications and Uses of Methotrexate 2.5mg Tablets
- Acute lymphoblastic leukemia
- Non-Hodgkin lymphoma
- Choriocarcinoma
- Rheumatoid arthritis
- Psoriasis
- Juvenile idiopathic arthritis
- Interstitial lung disease associated with rheumatoid arthritis
Side Effects of Methotrexate 2.5mg Tablets
- Nausea
- Mouth ulcers
- Fatigue
- Low blood cell counts (anemia, leukopenia, thrombocytopenia)
- Liver toxicity
- Kidney dysfunction
- Skin rashes or sensitivity
Storage and Handling
Store Methotrexate 2.5mg Tablets at room temperature, away from light and moisture. Keep out of reach of children, and do not use past the expiration date.
Patient Advice and Precautions
Before starting treatment, inform your doctor about any current medications or pre-existing conditions. Regular monitoring of blood counts, liver function tests, and kidney function tests is crucial during treatment. Hydration is important to help reduce the risk of kidney damage. Avoid vaccines without consulting your healthcare provider, and be cautious about potential drug interactions.