Medicine Description imutrexate 10 mg
imutrexate 10 mg tablets is a medication that primarily acts as an antimetabolite, inhibiting the enzyme dihydrofolate reductase (DHFR). This inhibition disrupts the synthesis of nucleic acids, particularly DNA and RNA, thereby affecting the proliferation of rapidly dividing cells, such as cancer cells. By interfering with folate metabolism, methotrexate reduces the availability of purines and pyrimidines, which are essential for cellular replication and function. This mechanism underlies its therapeutic effects in various malignancies and autoimmune disorders.
Indications and Uses of imutrexate 10 mg tablets
- Acute lymphoblastic leukemia
- Non-Hodgkin lymphoma
- Choriocarcinoma
- Psoriasis
- Rheumatoid arthritis
- Ectopic pregnancy
- Juvenile idiopathic arthritis
Side Effects of imutrexate 10 mg tablets
- Nausea
- Fatigue
- Mouth sores
- Hair loss
- Increased liver enzymes
- Bone marrow suppression
- Skin rash
Storage and Handling
Store imutrexate 10 mg tablets at room temperature, away from moisture and heat. Keep the medication in its original container and out of reach of children.
Patient Advice and Precautions
Patients should be counseled regarding the importance of regular blood tests to monitor liver function and blood cell counts during treatment. It is critical to stay well-hydrated and to inform healthcare providers about any signs of infection or unusual bruising or bleeding. Patients should also be advised to avoid alcohol and certain vaccinations while on this medication.