Pridocaine cream contains a combination of two local anaesthetics lidocaine & prilocaine. penetration & systemic absorption of this mixture is superior than each separate ingredient,shows more pain control than lidocaine alone. How do you use Pridocaine cream? Anaesthesia before minor skin procedures: Apply thick layer under occlusive dressing 1-5 hours before procedure (2-5 hours before procedures on large areas e.g. split skin grafting). Removal of warts from genital mucosa in adults, apply up to 10 g 5-10 minutes before removal. For Premature ejaculation: A small amount of Pridocaine cream to be applied on the tip of the penis 15 minutes before sexual intercourse.