EMLA Cream is an advanced topical medicated preparation that combines two potent anesthetics, lidocaine and prilocaine, at a balanced concentration of 2.5% each (5% total). This cream is specially formulated to provide temporary local anesthesia to the skin and mucous membranes, making it a valuable tool for reducing pain and discomfort associated with many superficial medical and cosmetic procedures. Thanks to its unique formulation, EMLA Cream provides effective pain relief while preserving skin integrity and minimizing the potential for systemic side effects. This cream is a reliable choice for individuals seeking a more comfortable experience during procedures that may cause tingling or superficial pain.
Active Ingredients in EMLA Cream
EMLA Cream's effectiveness is based on the synergistic combination of two local anesthetics that work together to provide effective anesthesia:
Lidocaine: 2.5% w/w. Lidocaine is a potent, fast-acting local anesthetic belonging to the amide class. It works by blocking the transmission of pain nerve signals to the area where it is applied.
Prilocaine: 2.5% w/w. Prilocaine is another amide local anesthetic similar in mechanism of action to lidocaine, but it may have some different pharmacological properties that contribute to the overall effectiveness of EMLA Cream.
This combination of lidocaine and prilocaine works synergistically to ensure effective anesthesia of the superficial layers of the skin and mucous membranes, reducing the sensation of pain during various procedures.
Mechanism of Action of EMLA Cream
EMLA Cream works via a dual mechanism to numb the applied area:
Blocking the transmission of nerve signals: Both lidocaine and prilocaine penetrate the layers of the skin and mucous membranes and interact with sensory nerve endings. They stabilize nerve membranes by preventing the influx of sodium ions into neurons. Sodium ions are necessary for the initiation and transmission of nerve impulses that transmit pain signals to the brain. Local Effect: The anesthetic effect is limited to the area directly applied, reducing the risk of systemic side effects affecting the entire body.
The cream takes a certain amount of time to produce the desired anesthetic effect, depending on the thickness of the skin and the area to which the cream is applied. Optimal effect is usually achieved approximately one hour after application under an adhesive bandage.
Indications for Use of EMLA Cream
EMLA Cream is widely used to provide local anesthesia before many medical and cosmetic procedures, including:
Needle Insertion: To relieve pain associated with blood sampling (blood draws), injections (such as vaccinations or insulin injections), and intravenous catheter insertion.
Minor Skin Procedures: Such as the removal of small moles, warts, and the curettage of superficial skin lesions.
Cosmetic Procedures: Such as laser hair removal, waxing, microneedling, and superficial filler and Botox injections.
Relief of pain from certain superficial skin conditions: such as relieving pain and itching associated with certain rashes or insect bites.
How to Use EMLA Cream
To ensure optimal anesthesia and maximum effectiveness, EMLA Cream must be used correctly:
Cleansing: The area to be anesthetized must be thoroughly cleaned and dried before applying the cream.
Application: A thick layer of cream is applied to the skin in the area to be anesthetized. The layer should be thick enough so that the skin cannot be seen through it.
Coverage (Recommended): To increase the effectiveness of the anesthesia, it is recommended to cover the area to which the cream has been applied with an adhesive bandage or plastic wrap. This helps prevent the cream from evaporating and increases the absorption of the anesthetic into the skin.
Waiting Time: The cream must be left on the skin for a sufficient period before the procedure. The recommended waiting period is usually at least one hour. Waiting time may vary depending on the type of procedure and skin thickness. Follow your doctor's instructions or the instructions on the product package.
Removal: Immediately before the procedure, remove the cream and clean the area thoroughly.