Calamine cream is widely used to soothe itchy and irritated skin due to its soothing and cooling properties. It is used to relieve itching and redness caused by various skin conditions such as chickenpox, rashes, insect bites, sunburn, and mild skin allergies. The cream works by forming a protective layer on the skin's surface, reducing itching and irritation. It also helps dry up fluids that may result from blisters or minor sores. Calamine also has anti-inflammatory properties, making it suitable for reducing swelling and discomfort associated with minor skin infections. The cream is usually applied to clean, dry skin several times daily as needed and left to dry to form a thin, protective layer.