About Sultamicillin Penicillins Mechanism of Action of Sultamicillin Sultamicillin is an oral form of the antibiotic combination ampicillin/sulbactam. It contains esterified ampicillin and sulbactam. Sulbactam is an irreversible inhibitor of most important beta - lactamases, that occur in penicillin- resistant organisms. Ampicillin is the bactericidal component of the combination, as it inhibits the biosynthesis of cell wall mucopeptide of many Gm +ve, Gm- ve aerobic and anaerobic bacteria. Indications for Sultamicillin 1.Upper respiratory tract infections including sinusitis, otitis media and tonsillitis. 2.Lower respiratory tract infections including bacterial pneumonias and bronchitis. 3.Urinary tract infections and Pyelonephritis. 4.Skin and soft tissue infections and gonococcal infections.