Rifampin capsules are a powerful and effective antibiotic used to treat certain types of serious bacterial infections, particularly tuberculosis and leprosy. These capsules contain the active ingredient rifampicin, which is available in 150 mg and 300 mg strengths. This drug is characterized by its ability to penetrate and affect bacterial cells, making it an essential component in complex treatment regimens for chronic and severe infections.
What are the ingredients in rifampin?
Rifampin capsules contain the following active ingredient:
Rifampicin: 150 mg or 300 mg.
In addition to this active ingredient, the capsules contain inactive ingredients to form the capsule.
Rifampin Indications
Rifampin capsules are used to treat:
Tuberculosis (TB): As an essential part of a combination therapy regimen (usually with other drugs such as isoniazid, pyrazinamide, and ethambutol) for pulmonary and extrapulmonary tuberculosis.
Leprosy: Also as part of multidrug therapy.
Bacterial endocarditis: In some cases, in combination with other antibiotics.
Certain types of methicillin-resistant Staphylococcus aureus (MRSA) infections: In specific and complicated cases.
For the prevention of bacterial meningitis: In people who have been in contact with certain types of bacteria that cause meningitis, such as Neisseria meningitidis or Haemophilus influenzae type b.
Treatment aims to eliminate the bacteria causing the infection, reduce symptoms, and prevent the spread or recurrence of the disease.
What are the dosages of rifampin?
Rifampin capsules should be taken as directed by your doctor. The dosage and duration of treatment depend largely on the type and severity of the infection, the patient's age, weight, and response.
For tuberculosis: The usual dosage is 10 mg/kg of body weight, once daily, with a maximum of 600 mg daily. It is usually taken with other medications for a long period (several months).
For leprosy: The dosage and duration vary depending on the treatment regimen followed.
For the prevention of meningitis: Specific doses are given for a short period.
It is preferable to take the capsules on an empty stomach (one hour before or two hours after a meal) to improve absorption.
Swallow the capsule whole with a glass of water.
It is very important to complete the entire course of treatment as prescribed by your doctor, even if symptoms improve, to ensure complete eradication of the bacteria and prevent the development of resistance.
What are the side effects of rifampin?
Rifampin capsules may cause some side effects, some of which are common and others can be serious:
Common side effects:
Orange or red discoloration of body fluids (urine, tears, sweat, saliva): This is normal and harmless. May permanently stain contact lenses.
Nausea, vomiting, diarrhea, abdominal pain.
Headache, dizziness.
Low fever, chills.