Choriomon ampoules are a potent injectable hormonal medication containing the active ingredient human chorionic gonadotrophin (HCG) at a concentration of 5,000 IU per ampoule, along with a small amount of lactose (10 mg) as an inactive ingredient. HCG belongs to a group of hormones known as gonadotrophins, which play vital and complex roles in regulating reproductive functions in both men and women. Choriomon is used under close medical supervision in conditions requiring hormonal stimulation, such as hypogonadism, sex hormone deficiency, ovulation induction in women experiencing difficulty conceiving, and the treatment of cryptorchidism in prepubescent boys.
The active ingredient in Choriomon ampoules
The therapeutic efficacy of Choriomon ampoules depends primarily on the presence of the following active ingredient at a specific and precise concentration:
Human chorionic gonadotrophin (HCG): 5,000 IU per ampoule. HCG is typically extracted from the urine of pregnant women and is a protein hormone with a structural similarity to the luteinizing hormone (LH) naturally produced by the body. This structural similarity allows it to bind to the same receptors in the gonads and exert similar biological effects.
In addition to HCG, the ampoule contains 10 mg of lactose, a sugar used as a filler or stabilizer during the drug's manufacturing process.
How Choriomon Ampoules Work
The HCG hormone in Choriomon Ampoules works by mimicking the action of luteinizing hormone (LH) in the body, resulting in specific hormonal effects that differ between men, women, and male children:
In women:
Stimulates egg maturation: HCG binds to LH receptors on the follicle cells in the ovaries, stimulating the final maturation of eggs within the ovarian follicles.
Stimulates ovulation: After egg maturation, HCG injections trigger the release of a mature egg from the ovary in a process known as ovulation, a crucial event for pregnancy.
Supports the corpus luteum: After ovulation, HCG maintains the function of the corpus luteum, a temporary structure in the ovary that produces progesterone, which is essential for supporting the uterine lining and creating a suitable environment for embryo implantation and maintaining early pregnancy.
In men:
Stimulating testosterone production: HCG binds to LH receptors on the Leydig cells in the testicles, stimulating them to produce testosterone, the primary male sex hormone responsible for the development of secondary sexual characteristics, sperm production, and maintaining sexual desire.
In prepubertal males:
Treatment of undescended testicles: In cases of cryptorchidism (one or both testicles not descending into the scrotum), HCG injections can stimulate testosterone production in sufficient quantities to stimulate the descent of the testicles to their normal position in the scrotum, provided there is no anatomical cause preventing descent.
Indications for use of Choriomon Ampoules
Choriomon Ampoules are used under the supervision of a specialist in the following cases:
In women:
Treatment of infertility resulting from anovulation or oligoovulation in women who have not responded to treatment with clomiphene citrate.
Ovulation stimulation as part of assisted reproductive techniques such as intrauterine insemination (IUI) and in vitro fertilization (IVF).
Luteal phase support after ovulation stimulation to increase the chances of embryo implantation and maintain early pregnancy.
In men:
Treatment of primary and secondary hypogonadism accompanied by testosterone deficiency.
Treatment of infertility resulting from reproductive hormone deficiency (hypogonadotropic hypogonadism).
In prepubertal males:
Treatment of cryptorchidism in cases where there is no anatomical obstacle to testicular descent. It is usually used after other hormonal therapy has failed or as an alternative.