Medicine Description imatinib 400 mg
imatinib tablets 400 mg is a medication that specifically targets and inhibits the activity of certain tyrosine kinases, particularly the BCR-ABL fusion protein, which is a result of the Philadelphia chromosome translocation in chronic myelogenous leukemia. By blocking these enzymes, imatinib prevents the proliferation of cancer cells and induces apoptosis in neoplastic cells. This targeted approach helps to manage the disease more effectively by reducing the signaling pathways that lead to uncontrolled cell growth.
Indications and Uses of imatinib tablets 400 mg
- Chronic myelogenous leukemia (CML)
- Gastrointestinal stromal tumors (GISTs)
- Other conditions associated with overactive tyrosine kinases as determined by a healthcare provider
Side Effects of imatinib tablets 400 mg
- Nausea
- Diarrhea
- Fatigue
- Skin rash
- Headache
- Fluid retention
Storage and Handling
Store imatinib tablets at room temperature, away from moisture and heat. Keep out of reach of children and avoid storing in places where the temperature may exceed normal room conditions.
Patient Advice and Precautions
Patients should be counseled to adhere strictly to the prescribed treatment regimen. Regular monitoring of blood counts and liver function tests is recommended. It is essential to report any unusual symptoms or side effects to a healthcare professional promptly. Additionally, patients should be advised not to consume grapefruit juice, as it may interact with the metabolism of imatinib.