Medicine Description diavance 1.25mg
Diavance 1.25mg Tablets is a medication that combines glibenclamide and metformin, targeting glycemic control in patients with type 2 diabetes. Glibenclamide, a sulfonylurea, stimulates pancreatic beta cells to release insulin, thereby lowering blood glucose levels. Metformin, a biguanide, enhances insulin sensitivity in peripheral tissues, particularly in muscle and fat, while decreasing hepatic glucose production through the inhibition of gluconeogenesis in the liver. This dual mechanism not only helps in improving overall glycemic control but also aids in weight management and can lead to favorable lipid profile changes.
Indications and Uses of Diavance 1.25mg Tablets
- Management of type 2 diabetes mellitus in adults who are not adequately controlled on diet and exercise alone.
- For patients who require multiple oral antidiabetic agents to achieve desired glycemic control.
- As an adjunct to insulin therapy in appropriate cases.
Side Effects of Diavance 1.25mg Tablets
- Gastrointestinal disturbances such as nausea, vomiting, and diarrhea.
- Hypoglycemia, particularly when used with other glucose-lowering agents.
- Weight gain due to insulin stimulation.
- Potential for lactic acidosis, especially in patients with renal impairment.
- Skin reactions including rash or pruritus.
Storage and Handling
Store at room temperature, away from moisture and heat. Protect from light and ensure that the medication is kept out of reach of children.
Patient Advice and Precautions
Patients should monitor their blood glucose levels regularly and report any symptoms of hypoglycemia, including dizziness, sweating, or confusion. It is crucial to maintain a balanced diet and engage in regular physical activity to enhance the effectiveness of the medication. Regular follow-ups with healthcare providers are essential for monitoring kidney function and overall diabetes management.