Medicine Description irintocan 20mg
Irintocan 20mg Ampoules is a medication that functions primarily as a topoisomerase I inhibitor. It disrupts the DNA replication process during the S phase of the cell cycle by binding to the topoisomerase I enzyme, which is responsible for unwinding DNA strands to allow for replication. Once irinotecan is administered, it converts to its active metabolite, SN-38, which binds to the enzyme-DNA complex, preventing the re-ligation of the DNA strands. This ultimately leads to DNA damage, triggering cell death, particularly in rapidly dividing cancer cells, thus making it effective in treating various cancers.
Indications and Uses of Irintocan 20mg Ampoules
- Metastatic colorectal cancer
- Cancer of the pancreas
- Small cell lung cancer
- Other solid tumors as determined by a healthcare professional
Side Effects of Irintocan 20mg Ampoules
- Diarrhea
- Nausea and vomiting
- Abdominal pain
- Fatigue
- Leukopenia (reduced white blood cell count)
- Thrombocytopenia (reduced platelet count)
- Hair loss
- Allergic reactions
Storage and Handling
Store Irintocan 20mg Ampoules in a cool, dry place away from direct light. Ensure it is kept out of reach of children and not frozen. Follow specific temperature storage guidelines as advised by a healthcare professional.
Patient Advice and Precautions
Patients should remain under close supervision during treatment with Irintocan, as it can cause severe side effects, including life-threatening diarrhea. It is crucial to report any unusual symptoms immediately. Hydration is important, particularly if diarrhea occurs. Regular blood tests may be necessary to monitor blood cell counts and liver function during treatment.