About Dexamethasone A potent synthetic glucocorticoid, Antiasthmatic, anti-inflammatory and immunosuppressant. Mechanism of Action of Dexamethasone The drug exerts it`s pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows it`s migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response. Indications for Dexamethasone 1.Inflammatory conditions 2.Allergic reactions 3.Shock 4.Anaphylaxis 5.Intra-articular and soft tissue inflammation 6.Asthma 7.Rheumatoid arthritis 8.Adrenal insufficiency 9.Tuberculous meningitis 10.Respiratory diseases 11.Malignancies 12.Cerebral oedema. 13.Acute gout 14.Nausea and vomiting