About Fluconazole A triazole derivative, A board range Antifungal. Mechanism of Action of Fluconazole Fluconazole is fungicidal or fungistatic depending on the drug concentrations. I t inhibits the conversion of Lanosterol to 14 demethyl Lanosterol by inhibiting the cytochromeP450 enzyme 14 alpha demethylase and impair ergosterol synthesis Interactions for Fluconazole Cimetidine: Decreased efficacy of fluconazole. Cyclosporine: Increase in serum cyclosporine plasma concentration. Hydrochlorothiazide: Reduction in renal clearance of fluconazole. Phenytoin: Efficacy of phenytoin enhanced. Rifampicin: Efficacy of fluconazole decreased, higher dosage required. Sulfonylureas: Efficacy of tolbutamide, glyburide and glipizide increased. Warfarin: Potentiates the anticoagulant effect resulting in increase in prothrombin time. Indications for Fluconazole 1.Oesophageal candidiasis 2.Oropharyngeal candidiasis 3.Vaginal candidiasis 4.Systemic candidiasis 5.Cryptoc