About Clozapine Dibenzodiazepine derivative , Atypical antipsychotic, Tranquilizer, anti-psychotic. Mechanism of Action of Clozapine Clozapine binds to dopamine receptors. It has more affinity towards D4 receptor than other Dopamine receptors i.e.D1, D2, D3 &D5 receptors. It exerts its antipsychotic activity by blocking the dopamine projections in the limbic system. It acts as a competitive Dopamine antagonist. Clozapine also produces alpha adrenergic blocking activity, anti-serotonin activity and anticholinergic activity. It also produces moderately potent anticholinergic but paradoxically induce salivation and H1 blocking activity. Interactions for Clozapine Anticholinergics: Anticholinergic effects may be potentiated. Antihypertensives: Hypotensive effects may be potentiated. CNS drugs: Caution is advised with concomitant use. Agents that suppress bone marrow function: Avoid concomitant use.