About Moxifloxacin A third generation synthetic fluoroquinolone Antibiotic, A broad spectrum antibiotic. Mechanism of Action of Moxifloxacin Moxifloxacin acts by inhibiting the enzyme DNA gyrase (Topoisomerase 2) and Topoisomerase 4.DNA gyrase helps in the formation of a highly condensed three dimensional structure of the DNA by its nicking and closing activity and also by introducing negative supercoil in to the DNA double helix. Moxifloxacin inhibits DNA gyrase which results in abnormal linkage between opened DNA and gyrase and negative supercoiling is impaired. This will inhibits transcription of DNA in to RNA and subsequent protein synthesis. Indications for Moxifloxacin 1.Pneumonia 2.Bronchitis 3.Sinusitis 4.Skin infections Interactions for Moxifloxacin Antiarrhythmic agents (amiodarone, bretylium, disopyramide, procainamide, quinidine, sotalol): The risk of threatening cardiac arrhythmias may be increased.