About Clomipramine Tricyclic Antidepressant (Tertiary Amine), Antiobsessional. Mechanism of Action Clomipramine acts by inhibiting the re-uptake of Noradrenaline, and Serotonin (5 HT) in the CNS nerve terminals.This will result in an increased concentration of neurotransmitters in the synaptic cleft and produces antidepressant effect. Indications 1.Depression, 2.Obsessive compulsive disorder, 3.Adjunctive treatment of cataplexy associated with narcolepsy. dose Adult: Depression: Initial dose: 10 mg at night. Dose can be gradually increased to 150 mg / day at night or in 3 - 4 divided doses. Maintenance dose: 30 - 50 mg daily Maximum dose: 250 mg / day Obsessive compulsive disorder: Initial dose: 25 mg at night. Dose can be gradually increased to 150 mg / day at night or in 3 - 4 divided doses.