About Cefaclor A second-generation cephalosporin antibiotic, Oral Broad-spectrum antibiotics. Mechanism of Action Cefaclor is a 2nd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Cefaclor inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cefaclor. Cefaclor has more activity against ampicillin resistant haemophilus influenzae and branhamella catarrhalis Indications for Cefaclor 1.Pneumonia & Pulmonary infections 2.Otitismedia 3.Urinary tract infections & genital tract infections 4.Pharyngitis & Tonsillitis 5.Skin & wound infections 6.Bronchitis & Sinusitis