About Flumethasone Topical steroids, Anti inflammatory and antipruritic drugs Mechanism of Action of Flumethasone Its mechanism of action is to inhibit arachidonic acids role in the biosynthesis of prostaglandins and leukotrienes. Flumethasone is active when it is not bound to the plasma protein transcortin Indications for Flumethasone Treatment of skin disorders (Dermatitis,Eczemia,Psoriasis) Inflammations of corticosteroid responsive dermatoses