About Benzoyl Peroxide Organic peroxide, antikeratolytic agent , topical bactericidal agent -antiseptic and bleaching agent. Mechanism of Action of Benzoyl Peroxide Benzoyl peroxide exerts its activity because of its oxidizing property. In the presence of water it liberates oxygen and this produces antibacterial activity. Benzoyl peroxide is a potent topical bactericidal agent that reduces Propionibacterium acne concentration by generating reactive oxygen species in the sebaceous follicle.It rapidly improves both inflammatory and non inflammatory lesions and therefore used in acne. Indications for Benzoyl Peroxide 1.Acne Interactions for Benzoyl Peroxide PABA sun screens may transiently discolour skin. Tretinoin: Concomitant use may cause significant skin irritation.