Mechanism of Action of Camphor Camphor acts as a rubefacient when it is rubbed on the skin and causes localized vasodilatation- which gives feelings of comfort and warmth. When applied gently on the skin, it acts as an anti-pruritic agent and creates a feeling of coolness, and a mild local anaesthetic effect and relieves itching. When ingested in small amounts, it creates feelings of warmth and comfort in the epigastrium. Camphor acts as a local anesthetic on the respiratory passageways and causing cough suppression. Pharmacokinets of Camphor Absorption: Well absorbed through the skin, Distribution: Widely distributed in the body and crosses the placenta, Metabolism: Metabolized in liver, Excretion: Excreted mainly through urine and a minor portion is excreted through lungs.