About Amitriptyline Tricyclic Antidepressant (Tertiary Amine), anticholinergic. Indications for Amitriptyline 1.Depression, 2.Prophylaxis of migraine, 3.Bulimia nervosa, 4.Nocturnal enuresis. Mechanism of Action of Amitriptyline Amitriptyline acts by inhibiting the re-uptake of Noradrenaline and Serotonin (5 HT) in the CNS nerve terminals .This will result in an increased concentration of neurotransmitters in the synaptic cleft and produces antidepressant effect. Amitriptyline more selectively inhibit reuptake of Serotonin than Noradrenaline. Amitriptyline also has anticholinergic activity. It is also useful in migraine prophylaxis. The monoamine uptake blocking property is related to migraine prophylactic activity. These are suited for patient with depression. Contra-indications of Amitriptyline 1.Hypersensitivity to Amitriptyline 2.Myocardial infarction 3.CHF 4.Severe liver disease