About Ceftriaxone Third Generation Cephalosporin antibiotic(Parenteral). Mechanism of Action of Ceftriaxone Ceftriaxone is a 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Ceftriaxone inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Ceftriaxone. Indications for Ceftriaxone 1.Meningitis 2.Septicaemia 3.Typhoid 4.UTI 5.Prophylaxis in surgical infections 6.Lower respiratory tract infections 7.Pneumonia 8.Pelvic inflammatory disease 9.STD 10.Bacteraemia