About Cefadroxil First Generation Cephalosporin, para-hydroxy derivative of cefalexin, Oral broad-spectrum antibiotic Mechanism of Action of Cefadroxil Cefadroxil is a 1st generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Cefadroxil inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like Cefadroxil