Glucophage XR extended-release tablets are used to treat type 2 diabetes mellitus. They help lower blood glucose
levels gradually and steadily. The medication contains Metformin Hydrochloride, which improves the body’s response to
insulin and reduces glucose production in the liver.
In Saudi Arabia Glucophage XR is formulated as an extended-release tablet, which helps minimize the gastrointestinal
side effects commonly associated with regular metformin. It is considered a first-line medication in diabetes
management plans, alongside a healthy diet and regular physical activity, and should be used under medical supervision
to adjust dosage and monitor results.
Ingredients of Glucophage XR
Available Strengths
Glucophage XR 500 mg – 30 tablets
Glucophage XR 1000 mg – 30 tablets
Glucophage 500 mg – 50 film-coated tablets
Glucophage 1000 mg – 30 film-coated tablets
Indications GLUCOPHAGE XR
Treatment of type 2 diabetes mellitus
Improvement of insulin resistance
Reduction of fasting and postprandial blood glucose levels
Used in certain cases of polycystic ovary syndrome (PCOS) under medical supervision
Dosage
The appropriate dose is determined by the physician. Common dosing includes:
500 mg once daily with food
The dose may be gradually increased up to 2000 mg daily depending on response
Usually taken once daily in the evening
Side Effects
Common side effects may include:
Nausea or stomach discomfort
Mild diarrhea at the beginning of treatment
Slight loss of appetite
Metallic taste in the mouth
Vitamin B12 deficiency with long-term use
Contraindications
The medication should be temporarily discontinued before contrast imaging procedures or major surgeries. Use with
caution in elderly patients or those at risk of dehydration. It should not be taken without regular medical follow-up.
Alternatives Available in Pharmacies
Metformin-Eva XR
Amophage
Cidophage
Meglucon
How to Use Glucophage XR Properly
Take the tablet with or after food
Swallow the tablet whole without crushing or chewing
Follow the prescribed diet plan
Monitor blood glucose levels regularly
Storage Conditions
Frequently Asked Questions
What is the best time to take Glucophage XR?
It is usually taken once daily with or after the evening meal to reduce stomach upset and maintain glucose control
throughout the day.
Which is better for weight loss: Glucophage or Glucophage XR?
Both contain the same active ingredient. XR may be better tolerated by the stomach. It is not primarily a weight-loss
medication but is used mainly for blood sugar control.
Does Glucophage 1000 affect the kidneys?
It does not harm healthy kidneys but should not be used in severe kidney impairment and requires kidney function
monitoring.
Does Glucophage burn fat?
It does not directly burn fat, but it may support modest weight reduction by improving insulin resistance and reducing
appetite.