About Mecobalamin Water soluble, Form of Vitamin B12 Mechanism of Action of Mecobalamin Mecobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes. Indications for Mecobalamin 1.Peripheral neuropathies 2.Megaloblastic anaemia Interactions for Mecobalamin 1.Decreased GI tract absorption with neomycin, aminosalicylic acid, H2-blockers and colchicines 2.Reduced serum concentrations with oral contraceptives 3.Reduced effects in anaemia with parenteral chloramphenicol