Tramacet tablets are an effective combination medication that combines the effects of two pain-relieving agents that work synergistically to provide powerful relief from moderate to severe pain. Each tablet contains a balanced combination of 325 mg of paracetamol, a well-known analgesic and antipyretic, and 37.5 mg of tramadol, a weak opioid pain reliever. Tramacet is used to relieve a variety of acute and chronic pain conditions that require stronger analgesia than non-opioid analgesics alone, helping patients improve their quality of life and reduce their pain.
The active ingredient in Tramacet tablets
The therapeutic efficacy of Tramacet tablets relies on the presence of two active ingredients that work synergistically to provide a powerful analgesic effect:
Paracetamol: Available in 325 mg per tablet, it is an effective analgesic and antipyretic. Paracetamol works by inhibiting the production of chemicals called prostaglandins in the brain and central nervous system, reducing pain and lowering fever.
Tramadol: Available in 37.5 mg strength per tablet, usually as tramadol hydrochloride. Tramadol is a weak opioid analgesic. It works by binding to opioid receptors in the brain and spinal cord, altering the way the body senses and responds to pain. Tramadol also inhibits the reuptake of norepinephrine and serotonin in the brain, which may also contribute to its analgesic effect.
This balanced combination of paracetamol and tramadol provides a stronger and more effective analgesic effect than either drug alone, while potentially reducing some of the side effects associated with high doses of either drug.
Mechanism of Action of Tramacet Tablets
Tramacet tablets work by combining two different but complementary mechanisms for effective pain relief:
Mechanism of Action of Paracetamol: It works primarily in the central nervous system to relieve pain and reduce fever. It is believed to inhibit the enzyme cyclooxygenase (COX), but in a manner different from nonsteroidal anti-inflammatory drugs (NSAIDs) and has little effect on inflammation.
Mechanism of Action of Tramadol: It works by binding to opioid receptors in the brain and spinal cord, reducing the transmission of pain signals to the brain and altering pain perception. It also inhibits the reuptake of the neurotransmitters norepinephrine and serotonin, increasing their levels in the brain. This may contribute to pain relief and improved mood.
This dual effect makes Tramacet an effective choice for relieving moderate to severe pain.