Gemique tablets are an effective oral antibiotic used to treat certain types of bacterial infections affecting the respiratory tract. This medication contains the active ingredient gemifloxacin at a concentration of 320 mg per tablet. Gemique belongs to the fluoroquinolone class of antibiotics, which is effective against a wide range of Gram-negative and Gram-positive bacteria that are often responsible for respiratory tract infections. Gemique tablets are primarily used to treat acute bacterial exacerbations of chronic bronchitis, community-acquired pneumonia, and acute bacterial sinusitis, helping to eliminate the infection and improve patients' symptoms.
The active ingredient in Gemique tablets
The therapeutic efficacy of Gemique tablets depends primarily on the following active ingredient:
Gemifloxacin: 320 mg per tablet. Gemifloxacin is a fourth-generation fluoroquinolone antibiotic characterized by its high ability to penetrate lung and respiratory tissues and its effective concentration at sites of infection.
Mechanism of Action of Gemique Tablets
Gemifloxacin works at the cellular level in bacteria to prevent them from reproducing and spreading. Its primary mechanism of action is:
Inhibition of DNA gyrase and topoisomerase IV: Gemifloxacin inhibits two essential bacterial enzymes, DNA gyrase and topoisomerase IV. These enzymes are essential for vital bacterial processes such as DNA replication, transcription, repair, and recombination.
Disruption of bacterial DNA functions: By inhibiting these enzymes, Gemifloxacin prevents bacteria from copying their genetic information or repairing any damage to their DNA. This leads to the accumulation of breaks in bacterial DNA and the cessation of cellular vital processes.
Bactericidal effect: As a result of disrupting DNA function, the bacterial cell cannot continue to live or divide, leading to its death and eliminating the infection. Therefore, gemifloxacin is considered a bactericidal antibiotic.
Indications for Use of Gemique Tablets
Gemique tablets are used to treat certain types of bacterial infections caused by gemifloxacin-sensitive bacteria, specifically those affecting the respiratory system, including:
Acute Bacterial Exacerbation of Chronic Bronchitis (ABECB): Used to treat acute exacerbations of chronic bronchitis when the cause is gemifloxacin-sensitive bacteria.
Community-acquired pneumonia (CAP): Used to treat pneumonia that occurs outside the hospital and is mild to moderate and caused by gemifloxacin-sensitive bacteria.
Acute bacterial sinusitis: Used to treat sinusitis caused by bacteria sensitive to gemifloxacin. The specialist physician determines the indications for use of Gemique based on a precise diagnosis of the case, the type of bacteria suspected, its sensitivity to the antibiotic, the severity of the infection, and the patient's general condition.