Targofloxin 750 tablets are a highly effective and powerful antibiotic belonging to the third-generation fluoroquinolone class. They contain the active ingredient levofloxacin at a concentration of 750 mg per tablet. Levofloxacin is characterized by its broad effectiveness against a wide spectrum of Gram-positive and Gram-negative bacteria, in addition to its ability to penetrate various tissues in the body and reach infection sites at effective therapeutic concentrations. Targofloxin 750 is typically used to treat severe and complicated bacterial infections that may not respond to other antibiotics or in cases that require strong and rapid treatment. Targo 750 tablets are an important treatment option for combating serious bacterial infections that threaten the patient's life.
The active ingredient in Targofloxin 750 tablets
The therapeutic efficacy of Targofloxin 750 tablets is primarily based on the following active ingredient:
Levofloxacin: 750 mg per tablet. This high concentration is typically used to treat severe infections or when lower doses are insufficient. Levofloxacin is a space isomer of ofloxacin and is more effective against certain types of bacteria.
Mechanism of Action of Targofloxin 750 Tablets
Levofloxacin acts at the bacterial DNA level, a critical target for their survival and reproduction. Its primary mechanism of action is:
Inhibition of DNA Gyrase and Topoisomerase IV: Levofloxacin inhibits two essential bacterial enzymes: DNA Gyrase and Topoisomerase IV. These enzymes are essential for vital bacterial processes such as DNA replication, transcription, repair, and recombination.
Disrupting bacterial DNA functions: By inhibiting these enzymes, levofloxacin prevents bacteria from copying their genetic information or repairing any damage to their DNA. This leads to the accumulation of breaks in bacterial DNA and the cessation of cellular vital processes.
Bactericidal effect: As a result of disrupting DNA functions, the bacterial cell cannot continue to live and divides, leading to its death and eliminating the infection. Therefore, levofloxacin is considered a bactericidal antibiotic, not just a growth inhibitor.
Indications for use of Targofloxin 750 Tablets
Targofloxin 750 Tablets are used to treat severe or complicated bacterial infections caused by bacteria sensitive to levofloxacin, including:
Community-acquired pneumonia (CAP): In cases requiring hospitalization or when other antibiotics are inappropriate.
Complicated Skin and Soft Tissue Infections (CSTIs): such as large abscesses, severe cellulitis, infected wounds, and ulcers that require aggressive antibiotic penetration.
Complicated Urinary Tract Infections (UTIs): including urinary tract infections affecting the kidneys or pelvis.
Acute Pyelonephritis: a bacterial infection of the kidneys.
Chronic Bacterial Prostatitis: a chronic bacterial infection of the prostate gland.
Anthrax Prophylaxis: after exposure to anthrax bacteria.
A specialist physician determines the indications for use of Targo 750 based on an accurate diagnosis of the case, the type and severity of the bacteria causing the infection, and the patient's general condition.