Orlistat capsules are an approved and effective medication used as a weight loss aid for people suffering from obesity or overweight accompanied by other weight-related health problems. Each capsule contains the active ingredient orlistat, a compound that uniquely works on the digestive system to prevent the absorption of some of the fats in the food consumed. Unlike many weight loss medications that act on the brain or appetite, orlistat works locally in the digestive system without significantly affecting the central nervous system. Orlistat is an important treatment option for people seeking to achieve healthy and sustainable weight loss as part of a comprehensive plan that includes dietary changes and increased physical activity.
The active ingredient in orlistat capsules
The effectiveness of orlistat capsules depends on the following active ingredient:
Orlistat: Typically, the standard strength is 120 mg per capsule for prescription or 60 mg for some non-prescription products. This concentration reduces the absorption of approximately 30% of dietary fat.
Mechanism of Action of Orlistat Capsules
Orlistat acts directly and specifically on the digestive system to disrupt the digestion and absorption of fats. Its primary mechanism of action is:
Inhibition of gastric and intestinal lipases: Orlistat binds strongly to lipases, which are fat-digesting enzymes produced by the stomach and pancreas. These lipases are responsible for breaking down triglycerides (fats found in most foods) into free fatty acids and other small molecules that can be absorbed through the intestinal wall.
Preventing Fat Breakdown: By inhibiting lipases, Orlistat prevents these enzymes from performing their function in breaking down fats.
Reducing Fat Absorption: As a result, a large portion of undigested fat passes unabsorbed through the intestine and is excreted in the stool. This reduces the amount of calories the body absorbs from fat, contributing to weight loss.
It is important to note that Orlistat does not inhibit the absorption of carbohydrates or proteins.
Indications for Use of Orlistat Capsules
Orlistat capsules are used as an adjunct to weight management in the following cases:
Obesity in adults and adolescents aged 12 years and older: particularly those with a BMI of 30 kg/m² or greater.
Overweight in adults with a BMI of 27 kg/m² or greater who also have other weight-related risk factors, such as high blood pressure, diabetes, or high cholesterol.
As an integral part of a comprehensive weight management program: This program should include a low-calorie, low-fat diet and regular physical activity to ensure optimal results and promote a healthy lifestyle in the long term.