Mykotral-H Cream is a topical medicated preparation specifically designed to treat fungal skin infections, especially those accompanied by inflammation, itching, and redness. This cream contains the active ingredient miconazole, an antifungal known for its effectiveness against a wide range of fungi and yeasts that cause skin infections. The letter "H" in the product name typically indicates that it contains another anti-inflammatory ingredient, most often a topical corticosteroid such as hydrocortisone or betamethasone. This ingredient works to reduce the inflammation, redness, swelling, and itching associated with fungal infections, providing rapid relief. Mykotral-H Cream represents a comprehensive treatment option that targets both the causative agent of the fungal infection and the associated inflammatory symptoms.
The active ingredient in Mykotral-H Cream
The therapeutic efficacy of Mykotral-H Cream depends on the combined action of two main active ingredients:
Miconazole: An antifungal belonging to the azole class. The standard concentration is usually 2%, but the exact concentration varies depending on the specific product and manufacturer. Miconazole works to stop the growth of fungi and kill them.
An anti-inflammatory ingredient (often a corticosteroid such as hydrocortisone): The exact concentration of this ingredient also varies, but its presence helps reduce the inflammatory response of the affected skin.
Always check the package insert for the exact concentrations of the active ingredients.
Mechanism of Action of Mykotral-H Cream
Mykotral-H Cream works through a dual mechanism of action to combat fungal infections and inflammation:
Antifungal Effect of Miconazole: Miconazole works by inhibiting a specific enzyme in fungi called cytochrome P450 14 alpha demethylase, which is necessary for the synthesis of ergosterol. Ergosterol deficiency leads to weakness and fragility in the fungal cell membrane, causing leakage of internal cell components and fungal cell death.
Anti-inflammatory effect: The corticosteroid in the cream inhibits the release of chemicals produced by skin cells in response to inflammation, such as prostaglandins, leukotrienes, and cytokines. This inhibition reduces redness, swelling, itching, and pain in the affected area, providing rapid relief and helping to reduce itching that can exacerbate the condition.
This combination of effects allows for effective treatment of fungal infections while controlling the associated inflammatory symptoms.