Bambedil syrup is an oral liquid medicine specifically designed to treat respiratory conditions involving airway obstruction, such as asthma. This syrup contains the active ingredient bambuterol hydrochloride at a concentration of 5 mg per 5 ml. Bambuterol belongs to a group of long-acting beta2 agonists and is characterized by its ability to provide a bronchodilator effect that lasts for up to 24 hours after a single dose. Bambedil syrup is a suitable option for controlling the symptoms of chronic asthma, especially in children and those who find it difficult to use inhalers or swallow tablets. It provides relief from wheezing, shortness of breath, and coughing associated with asthma, helping to improve patients' quality of life, their ability to perform daily activities, and their ability to sleep comfortably.
The active ingredient in Bambedil Syrup
The therapeutic efficacy of Bambedil Syrup is primarily based on the following active ingredient:
Bambuterol Hydrochloride: 5 mg per 5 ml of syrup. Bambuterol is a prodrug that is not biologically active itself, but acts as a reservoir for the active metabolite terbutaline, a selective beta2-adrenergic agonist. Bambuterol is slowly converted in the body to terbutaline, resulting in sustained release of the active metabolite and a long-lasting effect.
Mechanism of Action of Bambedil Syrup
The active ingredient in Bambedil Syrup works through a mechanism of conversion and metabolism to ensure a sustained therapeutic effect and bronchodilator effect:
Absorption and Metabolism: After oral administration of Bambedil Syrup, bambuterol is absorbed from the gastrointestinal tract and slowly undergoes metabolism in the liver and intestines to the active metabolite terbutaline. Beta-2 receptor activation: Terbutaline binds to and activates beta-2 receptors found abundantly on the surface of smooth muscle cells lining the bronchi.
Smooth muscle relaxation and bronchodilation: Activation of beta-2 receptors increases intracellular levels of cyclic adenosine monophosphate (cAMP), which leads to relaxation of the smooth muscles in the bronchial walls. This relaxation causes bronchial dilation and reduces airflow resistance, facilitating breathing and relieving asthma symptoms.
Long-term effect: Due to the slow and gradual conversion of bambuterol to terbutaline, the blood concentration of the active metabolite terbutaline remains sufficiently high for up to 24 hours, providing sustained relief from asthma symptoms and reducing the frequency of attacks.
Indications for use of Bambedil Syrup
Bambedil Syrup is used as a maintenance and symptom-preventing treatment in the following conditions:
Chronic asthma: It is used to control symptoms of chronic asthma, such as wheezing, shortness of breath, and cough, and to reduce the frequency of attacks, especially in children and adults whose symptoms are not adequately controlled with other treatments. It is not used to relieve sudden acute asthma attacks.
Chronic bronchitis and reversible airway obstruction: It may be used to help relieve airway obstruction associated with these conditions.