About Telmisartan Angiotensin II Receptor antagonist, Antihypertensive. Mechanism of Action of Telmisartan It is a competitive antagonist of angiotensin-2 at AT-1 receptor. It decreases peripheral resistance and lowers BP in hypertensive individuals. It blocks all overt actions of angiotensin-2 such as: - 1. Vasoconstriction, 2. Central & Peripheral sympathetic stimulus, 3. Release of aldosterone and adrenaline, 4. Salt and water reabsorption, 5. Central actions like thirst, vasopressin release, and growth promoting actions on heart and blood vessels. Indications for Telmisartan 1.Hypertension Typical Dosage for Telmisartan 40mg once daily Maintenance dose: 20 to 80mg once daily