About Pregabalin A GABA agonist, Anticonvulsant. Mechanism of Action of Pregabalin Pregabalin is a GABA neurotransmitter analog. It produces its action by modulating calcium channels and also reduces the release of neurotransmitters such as Glutamate, Norepinephrine, Serotonin, Dopamine and Substance P. Indications for Pregabalin 1.Epilepsy 2.Generalised anxiety disorder 3.Neuropathic pain Typical Dosage for Pregabalin 150- 300mg / day in 2 divided doses