About Bromocriptine Dopamine Agonist, Ergot- Alkaloid, Anti Parkinsonsm, hypoprolactinemic. Mechanism of Action of Bromocriptine Bromocriptine is a dopaminergic agonist. It acts as a potent agonist on D2 receptor and partial agonist or antagonist on D1 receptor. Bromocriptine produces a decrease in Dopamine turnover with increase in Dopamine content of the brain and decreases the metabolism of Dopamine. The increase in Dopamine concentration produces effect in Parkinson`s disease. Since Dopamine is a neurotransmitter in the brain it can produces various motor, behavioural and endocrine effects. Hormonal action: Bromocriptine inhibits synthesis and release of Prolactin from pituitary lactotrope cell by acting as a D2 agonist. Indications for Bromocriptine 1.Parkinson`s disease 2.Amenorrhea and Galactorrhea associated with hyperprolactinemia 3.Acromegaly 4.Hepatic encephalopathy 5.Premenstrual syndrome 6.Cushing`s syndrome 7.Suppression of established lactation.