About Crotamiton Antiparasitic Agent, Pediculicide, scabicidal , and antipruritic. Mechanism of Action of Crotamiton Crotamiton exerts its pharmacological action (pruritis) by virtue of its counter irritant property. After topical application it produces a cooling effect. This cooling effect counteracts the body`s attention from itching. Indications for Crotamiton 1.Pruritis 2.Pediculocide 3.Scabicide Side Effects of Crotamiton 1.Irritation 2.Hypersensitivity reactions 3.Pruritus 4.Contact dermatitis 5.Rashes 6.Warm sensation 7.Allergy 8.Pallor and cyanosis after extensive application