Indications for Atorvastatin + Amlodipine This is a combination of calcium channel blocker, Amlodipine and HMG-CoA reductase inhibitor Atorvastatin. The combination generic is used to treat 1.Hypertension 2.Angina (that occurs with high cholesterol or triglyceride levels) Typical Dosage for Atorvastatin + Amlodipine Adult:1 tablet / day Mechanism of Action of Atorvastatin It is a more potent statin which competitively inhibits the conversion of 3-hydroxy-3-methyl glutaryl coenzyme A (HMG CoA) to mevalonate. The drug exerts it`s action by specific inhibition of enzyme- 3-hydroxy-3-methyl glutaryl coenzyme A reductase (HMG CoA reductase) and reduces cholesterol synthesis up to 50% at therapeutic doses. This results in compensatory increase in low density lipoprotein (LDL) receptor expression in liver which ultimately leads to increased receptor mediated uptake and catabolism of intermediate density lipoprotein(IDL) and low density lipoprotein (LDL).