About Eszopiclone Benzodiazepine agonist, sedative and hypnotics. Mechanism of Action of Eszopiclone Eszopiclone acts on benzodiazepine binding site situated on GABAA neurons as an agonist, increases the conduction of chloride ions across the neuronal cell membrane .This increased conductance raises the membrane potential of the neuron, resulting in inhibition of neuronal firing. Indications for Eszopiclone 1. Insomnia 2. Behavioral therapies Typical Dosage for Eszopiclone Adult: 2 mg to 3 mg before bed time Older patient: 2 mg before bed time