Medicine Description cytarabine-human-care 20mg
Cytarabine 20 mg injection is a medication that belongs to the class of antimetabolites. Its active ingredient, cytarabine, mimics the nucleoside cytidine, allowing it to be incorporated into DNA during the S-phase of the cell cycle. Once incorporated, it inhibits DNA polymerase, disrupting DNA synthesis and repair processes. This interference with the replication of genetic material ultimately leads to programmed cell death (apoptosis) in rapidly dividing cancer cells, thereby reducing tumor growth and progression. Cytarabine's effectiveness is particularly evident in hematologic malignancies where rapid cell division is a hallmark.
Indications and Uses of Cytarabine 20 mg injection
- Acute myeloid leukemia (AML)
- Acute lymphoblastic leukemia (ALL)
- Non-Hodgkin lymphoma
- Chronic myeloid leukemia (CML)
- Cytarabine is also used in some cases as part of conditioning regimens before stem cell transplantation.
Side Effects of Cytarabine 20 mg injection
- Nausea and vomiting
- Bone marrow suppression
- Fatigue
- Hair loss
- Mucositis (inflammation of the mucous membranes)
- Increased risk of infections
- Fever
- Liver function abnormalities
Storage and Handling
Store Cytarabine 20 mg injection at 20°C to 25°C (68°F to 77°F) in a tightly closed container, protected from light. It should not be frozen and must be kept out of reach of children.
Patient Advice and Precautions
Patients should be counseled to report any signs of infection, unusual bleeding, or severe side effects immediately. Hydration is crucial during treatment to help mitigate side effects. Regular blood tests will be necessary to monitor blood counts and liver function. Pregnant or breastfeeding women should avoid this medication due to potential harm to the fetus or infant.