About Fluorometholone (Eye.Prep.) A Synthetic Glucocorticoid, In steroid responsive inflammations of Eye( topical anti-inflammatory). Mechanism of Action of Fluorometholone (Eye.Prep.) The drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. This structural change allows its migration in to the nucleus and then binding to specific sites on the DNA which leads to transcription of specific m-RNA and which ultimately regulates protein synthesis. It exerts highly selective glucocorticoid action. It stimulates the enzymes needed to decrease the inflammatory response.