About Felodipine A Selective calcium channel blocker, Dihydropyridine derivative, Anti hypertensive. Mechanism of Action of Felodipine Felodipine is a vasoselective long acting dihydropyridine Ca channel blocker. It exerts antihypertensive, antianginal actions through blocking the influx of Ca2+ ions through voltage gated L-type Ca channels to the peripheral vascular smooth muscle cells, Coronary smooth muscle cells and to the myocardial cells. Thus causes dilatation of vascular endothelium, decrease peripheral resistance, & reduce myocardial oxygen demand .It has smooth muscle relaxant action produces by release of nitric oxide from endothelium and thus inhibit cyclic AMP-phosphodiesterase resulting in raised cyclic AMP in smooth muscle. Nitric oxide exerts anti atherosclerotic action.