About Gemcitabine Antimetabolite ,a nucleoside(Pyrimidine) Analog, Antineoplastic. Mechanism of Action of Gemcitabine Gemcitabine is metabolized intracellularly to 2 active metabolites, Gemcitabine diphosphate and Gemcitabine triphosphate by the enzyme nucleoside kinase.This triphosphate metabolites of drugs are incorporated into DNA with the assistance of Gemcitabine diphosphate which results the inhibition of DNA synthesis and induction of apoptosis. This reaction is cell-cycle phase specific Indications for Gemcitabine 1. Lung cancer 2. Cervical cancer 3. Cancer of pancreas 4. Bladder cancer 5. Breast cancer 6. Lymphoma 7. Bile duct cancer 8. Cancer of gall bladder 9. Cancer of ovary 10. Cancer of testes 11. Head and neck cancer 12. Hodgkins disease 13. Esophageal cancer