About Ropivacaine Amide type local anaesthetics Mechanism of Action of Ropivacaine Ropivacaine blocks both initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions, resulting in inhibition of depolarisation with resultant blockade of conduction Indications for Ropivacaine 1.Surgical anaesthesia 2.Acute pain Interactions for Ropivacaine Itraconazole, ketoconazole or clarithromycin may reduce clearance of ropivacaine Increased metabolism when used with rifampicin Clearance is inhibited when used with fluvoxamine or ciprofloxacin Increased risk of toxicity when used with other local anaesthetics