About Diazepam A benzodiazepine derivative with CNS depressant, Anxiolytic, anticonvulsant, hypnotic, sedative, skeletal muscle relaxant and amnestic. Mechanism of Action of Diazepam Diazepam mainly acts on Limbic system and ascending reticular formation in the CNS and binds to the BZD receptor. The binding will facilitates GABA mediated chloride channel opening and produce hyperpolarisation. This will produce an increase in the concentration of the inhibitory neurotransmitter GABA and chloride ions and decreases firing rate of neuron. These in turn alters normal functions of the body. Antivertigo action: Although intravenous diazepam has been used to abort acute attacks of vertigo of peripheral origin, it can prolong compensation and recovery from vestibular lesions Interactions for Diazepam Alcohol and other CNS depressants: Enhanced CNS effects. Aminophylline: Antagonizes the sedative effect. Cimetidine, Oral contraceptives, Disulfiram, Fluoxetine, Isoniazid