About Piribedil A piperazine derivative,Dopamine agonist, Antiparkinsonism, Antidyskinetic. Mechanism of Action of Piribedil The exact mechanism of action is not known. A lesion in the Nigra striatum may be responsible for Parkinson`s disease which results in a reduction in Dopamine concentrations. This in turn causes a relative imbalance between dopaminergic and cholinergic neurological pathways. Piribedil crosses the Blood brain barrier and it act on the cerebral dopaminergic pathways. It stimulates dopaminergic receptors (D2 & D3) and restores effective neurotransmission. Indications for Piribedil 1.Parkinson`s disease 2.Symptoms and signs of cerebral ageing 3.Memory and vigilance disorders 4.Disorders of intellectual function Typical Dosage for Piribedil Parkinson`s disease Monotherapy: 50 - 250 mg /day in divided doses with meals. Dose is depending on patient`s response, Adjuvant therapy: 80 - 140 mg daily. Cerebral ageing: 150 mg / day with principle meal