About Oxaprozin Propionic acid derivative,NSAID,antiarthritic. Mechanism of Action of Oxaprozin Oxaprozin is a propionic acid derivative NSAID.Anti-inflammatory effects of Oxaprozin are believed to be due to inhibition of cylooxygenase in platelets which leads to the blockage of prostaglandin synthesis. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation. Oxaprozin is a non-selective NSAID, with a cell assay system showing lower COX-2 selectivity implying higher COX-1 selectivity. Indications for Oxaprozin 1.For relief of the signs and symptoms of osteoarthritis. 2.For relief of the signs and symptoms of rheumatoid arthritis. 3.For relief of the signs and symptoms of juvenile rheumatoid arthritis. Interactions for Oxaprozin 1.Increased risk of salicylate toxicity with aspirin 2.May increase effects of oral anticoagulants 3.May reduce effects of ?-blockers, diuretics